REVIEW PAPER
CANCER BIOMARKERS AND HEALTH SYSTEMS: THE DYNAMICS OF
A SCIENTIFICALLY BASED TRANSFORMATION
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1
Department of Pharmacy Services, Vocational School, Istanbul Beykent University, Istanbul, Türkiye
2
Department of Medical Documentation and Secretarial Services, Vocational School, Istanbul Beykent University, Istanbul, Türkiye
These authors had equal contribution to this work
Submission date: 2025-08-25
Final revision date: 2025-10-12
Acceptance date: 2025-10-20
Publication date: 2025-10-29
KEYWORDS
TOPICS
ABSTRACT
Cancer biomarkers are molecular markers that play a crucial role in the diagnosis, treatment, and monitoring of cancer. These markers enable more accurate patient classification and the development of personalized treatment strategies. The effect of genetic differences on the disease process necessitates the use of biomarkers in clinical decision-making. Advanced analysis technologies and multi-biomarker panels have increased diagnostic accuracy and facilitated the monitoring of treatment responses. Integrating biomarkers into healthcare policies expands opportunities for early diagnosis, enables more effective management of treatment processes, and increases the cost-effectiveness of healthcare services. Advanced technologies, such as artificial intelligence, nanotechnology, and big data analysis, enhance the sensitivity and specificity of biomarkers, thereby strengthening the success of precision medicine applications. These innovations enable the development of personalized treatment approaches and contribute to the sustainability of healthcare systems. In this context, the integration of biomarkers into health policies expands early diagnostic opportunities, improves service quality, and contributes to the creation of sustainable health systems. It is critically important for policymakers to consider scientific accuracy, patient safety, and ethical principles when evaluating these technological advances in order to effectively manage future health issues.
REFERENCES (47)
1.
International Agency for Research on Cancer. Global cancer burden growing, amidst mounting need for services. Press Release No. 345 [Internet]. Geneva: World Health Organization; 2024 [access 2025 Jun 17]. Available from:
https://www.iarc.who.int/wp-co....
2.
Hristova VA, Chan DW. Cancer biomarker discovery and translation: proteomics and beyond. Expert Rev Proteomics. 2019; 16(2): 93-103.
https://doi.org/10.1080/147894....
4.
Srivastava A, Creek DJ. Discovery and validation of clinical biomarkers of cancer: a review combining metabolomics and proteomics. Proteomics. 2019; 19(10): e1700448.
https://doi.org/10.1002/pmic.2....
5.
Zhou Y, Tao L, Qiu J, Xu J, Yang X, Zhang Y, et al. Tumor biomarkers for diagnosis, prognosis and targeted therapy. Signal Transduct Target Ther. 2024; 9(1): 132.
https://doi.org/10.1038/s41392....
6.
Ren AH, Fiala CA, Diamandis EP, Kulasingam V. Pitfalls in cancer biomarker discovery and validation with emphasis on circulating tumor DNA. Cancer Epidemiol Biomarkers Prev. 2020; 29(12): 2568-2574.
https://doi.org/10.1158/1055-9....
7.
Costa-Pinheiro P, Montezuma D, Henrique R, Jerónimo C. Diagnostic and prognostic epigenetic biomarkers in cancer. Epigenomics. 2015; 7(6): 1003-1015.
https://doi.org/10.2217/epi.15....
9.
DeLouize AM, Eick G, Karam SD, Snodgrass JJ. Current and future applications of biomarkers in samples collected through minimally invasive methods for cancer medicine and population-based research. American Journal of Human Biology. 2022; 34(11): e23665.
https://doi.org/10.1002/ajhb.2....
10.
Pal M, Muinao T, Boruah HPD, Mahindroo N. Current advances in prognostic and diagnostic biomarkers for solid cancers: detection techniques and future challenges. Biomedicine & Pharmacotherapy. 2022; 146: 112488.
https://doi.org/10.1016/j.biop....
13.
Louie AD, Huntington K, Carlsen L, Zhou L, El-Deiry WS. Integrating molecular biomarker inputs into development and use of clinical cancer therapeutics. Frontiers in Pharmacology. 2021; 12.
https://doi.org/10.3389/fphar.....
14.
Karadag A. [Personalized medicine, integrated multi-omics artificial intelligence-based smart health system]. Turkish Association for Cancer Research and Control; 2022 (in Turkish).
16.
Chen J, Wu X, Han G, Xu C. Single-cell transcriptomic insights into ccRCC: a stemness gene signature for prognosis and treatment response prediction. Discov Onc. 2025; 16: 1862.
https://doi.org/10.1007/s12672....
17.
Simão TA, Gomes JV, de Paula JG, de Oliveira Ribeiro SC. Perspective chapter: advancements in cancer biomarkers – transforming diagnostics and therapeutic strategies in precision oncology. In: Gaina G, editor. Molecular diagnostics – current approaches and their clinical applications. London: IntechOpen; 2025.
https://doi.org/10.5772/intech....
18.
Abbasi AF, Naveed S, Asim MN, Sajjad M, Vollmer S, Dengel A. Artificial intelligence powered biomarker discovery: a large-scale analysis of 236 studies across 19 therapeutic areas and 147 diseases. bioRxiv. 2025.
https://doi.org/10.1101/2025.0....
19.
Lohajová Behulová R, Bugalová A, Bugala J, Struhárňanská E, Šafranek M, Juráš I, et al. Circulating exosomal miRNAs as a promising diagnostic biomarker in cancer. Physiol Res. 2023; 72(S3): S193-S207.
https://doi.org/10.33549/physi....
20.
Zakari S, Niels NK, Olagunju GV, Nnaji PC, Ogunniyi O, Tebamifor M, et al. Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review. Front Oncol. 2024; 14.
https://doi.org/10.3389/fonc.2....
21.
Mokhtari RB, Sambi M, Shekari F, Satari K, Ghafoury R, Ashayeri N, et al. A comprehensive oncological biomarker framework guiding precision medicine. Biomolecules. 2025; 15(9): 1304.
https://doi.org/10.3390/biom15....
22.
Ahmad AKM, Imran M, Ahsan H. Biomarkers as biomedical bioindicators: approaches and techniques for the detection, analysis, and validation of novel biomarkers of diseases. Pharmaceutics. 2023; 15(6): 1630.
https://doi.org/10.3390/pharma....
23.
Dakal TC, Dhakar R, Beura A, Moar K, Maurya PK, Sharma NK, et al. Emerging methods and techniques for cancer biomarker discovery. Pathol Res Pract. 2024; 262: 155567.
https://doi.org/10.1016/j.prp.....
24.
Bommi JR, Kummari S, Lakavath K, Sukumaran RA, Panicker LR, Marty JL, et al. Recent trends in biosensing and diagnostic methods for novel cancer biomarkers. Biosensors. 2023; 13(3): 398.
https://doi.org/10.3390/bios13....
25.
Molla G, Bitew M. The future of cancer diagnosis and treatment: unlocking the power of biomarkers and personalized molecular-targeted therapies. J Mol Pathol. 2025; 6(3): 20.
https://doi.org/10.3390/jmp603....
26.
Wang Z, Zou X, Wang H, Hao Z, Li G, Wang S. Companion diagnostics and predictive biomarkers for PD-1/PD-L1 immune checkpoint inhibitors therapy in malignant melanoma. Front Immunol. 2024; 15: 1454720.
https://doi.org/10.3389/fimmu.....
27.
Najafi NN, Hajihassani H, Azimzadeh Irani M. The impact of artificial intelligence on cancer diagnosis and treatment: a review. Cancer Inform. 2025; 24: 11769351251371273.
https://doi.org/10.1177/117693....
28.
Atout M, Elwaheidi H, Maarouf R, Albabtain AA, Alhayli S, Alshaibani A, et al. Minimal residual disease testing for diffuse large b cell lymphoma. Clin Lymphoma Myeloma Leuk. 2025; 25(10): e750-e755.
https://doi.org/10.1016/j.clml....
29.
Seijo LM, Peled N, Ajona D, Boeri M, Field JK, Sozzi G, et al. Biomarkers in lung cancer screening: achievements, promises, and challenges. J Thorac Oncol. 2019; 14(3): 343-357.
https://doi.org/10.1016/j.jtho....
30.
Chakraborty S, Sharma G, Karmakar S, Banerjee S. Multi-OMICS approaches in cancer biology: new era in cancer therapy. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 2024; 1870(5): 167120.
https://doi.org/10.1016/j.bbad....
31.
Tsimberidou AM, Fountzilas E, Nikanjam M, Kurzrock R. Review of precision cancer medicine: Evolution of the treatment paradigm. Cancer Treat Rev. 2020; 86: 102019.
https://doi.org/10.1016/j.ctrv....
32.
Prabhash K, Advani SH, Batra U, Biswas B, Chougule A, Ghosh M, et al. Biomarkers in non-small cell lung cancers: Indian Consensus Guidelines for Molecular Testing. Advances in Therapy. 2019; 36(4): 766-85.
https://doi.org/10.1007/s12325....
33.
Zoon CK, Starker EQ, Wilson AM, Emmert-Buck MR, Libutti SK, Tangrea MA. Current molecular diagnostics of breast cancer and the potential incorporation of microRNA. Expert Review of Molecular Diagnostics. 2009; 9(5): 455-466.
https://doi.org/10.1586/erm.09....
34.
Engstrom PF, Bloom MG, Demetri GD, Febbo PG, Goeckeler W, Ladanyi M, et al. NCCN molecular testing white paper: effectiveness, efficiency, and reimbursement. Journal of the National Comprehensive Cancer Network J Natl Compr Canc Netw. 2011; 9(Suppl_6): S-1-S-16.
https://doi.org/10.6004/jnccn.....
35.
Netto GJ, Cheng L. Emerging critical role of molecular testing in diagnostic genitourinary pathology. Arch Pathol Lab Med. 2012; 136(4): 372-390.
https://doi.org/10.5858/arpa.2....
36.
Febbo PG, Ladanyi M, Aldape KD, De Marzo AM, Hammond ME, Hayes DF, et al. NCCN Task Force report: evaluating the clinical utility of tumor markers in oncology. J Natl Compr Canc Netw. 2011; 9(Suppl. 5): S1-32.
https://doi.org/10.6004/jnccn.....
37.
Kulasingam V, Diamandis EP. Tissue culture-based breast cancer biomarker discovery platform. International Journal of Cancer. 2008; 123(9): 2007-2012.
https://doi.org/10.1002/ijc.23....
38.
Purkayastha K, Dhar R, Pethusamy K, Srivastava T, Shankar A, Rath GK, et al. The issues and challenges with cancer biomarkers. Journal of Cancer Research and Therapeutics. 2023; 19(Suppl. 1): S20-S35.
https://doi.org/10.4103/jcrt.j....
39.
Lewis JM, Heineck DP, Heller MJ. Detecting cancer biomarkers in blood: challenges for new molecular diagnostic and point-of-care tests using cell-free nucleic acids. Expert Rev Mol Diagn. 2015; 15(9): 1187-200.
https://doi.org/10.1586/147371....
40.
Kuhlmann E, Lotta G, Dussault G, Falkenbach M, Correia T. The workforce crisis in healthcare: moving the debate to bridge evidence and policy. The International Journal of Health Planning and Management. 2024; 39(3): 607-613.
https://doi.org/10.1002/hpm.37....
41.
Shahazi R, Saddam AI, Islam MR, Rahman MM, Paimard G, Kumer A, et al. Recent progress in Nanomaterial based biosensors for the detection of cancer biomarkers in human fluids. Nano Carbons. 2024; 2(2): 1254.
https://doi.org/10.59400/n-c.v....
42.
Lawal AO, Ogunniyi TJ, Oludele OI, Olorunfemi OA, Okesanya OJ, Ogaya JB, et al. Innovative laboratory techniques shaping cancer diagnosis and treatment in developing countries. Discover Oncology. 2025; 16(1): 137.
https://doi.org/10.1007/s12672....
43.
Restrepo JC, Dueñas D, Corredor Z, Liscano Y. Advances in genomic data and biomarkers: revolutionizing NSCLC diagnosis and treatment. cancers. 2023; 15(13): 3474.
https://doi.org/10.3390/cancer....
44.
Molla G, Bitew M. Revolutionizing personalized medicine: synergy with multi-omics data generation, main hurdles, and future perspectives. Biomedicines. 2024; 12(12): 2750.
https://doi.org/10.3390/biomed....
45.
Alsaedi S, Ogasawara M, Alarawi M, Gao X, Gojobori T. AI-powered precision medicine: utilizing genetic risk factor optimization to revolutionize healthcare. NAR Genomics and Bioinformatics. 2025; 7(2).
https://doi.org/10.1093/nargab....
46.
Nwankwo EI, Emeihe EV, Ajegbile MD, Olaboye JA, Maha CC. AI in personalized medicine: enhancing drug efficacy and reducing adverse effects. International Journal of Biology and Pharmacy Research Updates. 2024; 4(8): 806-833.
https://doi.org/10.51594/imsrj....
47.
Obijuru A, Arowoogun JO, Onwumere C, Odilibe IP, Anyanwu EC, Daraojimba AI. Big data analytics in healthcare: a review of recent advances and potential for personalized medicine. International Medical Science Research Journal. 2024; 4(2).
https://doi.org/10.51594/imsrj....