REVIEW PAPER
NEWLY-EMERGING SIDE EFFECTS OF SEMAGLUTIDE AND LIRAGLUTIDE USAGE ASSOCIATED WITH WEIGHT LOSS TREATMENT
1
Military Medical Academy Memorial Teaching Hospital of the Medical University of Lodz, Central Veteran Hospital, Lodz, Poland
2
S. Zeromski Specialist Hospital, Cracow, Poland
3
Faculty of Medicine, Medical College, Jagiellonian University, Cracow, Poland
4
Karol Jonscher Municipal Medical Center, Lodz, Poland
5
Mikolaj Pirogow Provincial Specialist Hospital, Lodz, Poland
6
Maria Skłodowska-Curie Specialist Hospital, Brzeziny, Poland
7
Nicolaus Copernicus Specialist Hospital, Lodz, Poland
Submission date: 2024-05-14
Acceptance date: 2024-06-07
Publication date: 2024-06-13
KEYWORDS
TOPICS
ABSTRACT
GLP-1 agonists, such as semaglutide and liraglutide, are some of the most promising drugs in therapy for treating obesity in patients with type 2 diabetes as well as patients without diabetes. With many positive effects, not only in treating obesity but also in positively affecting blood glucose levels, blood pressure and cardiac muscle, they are among the most commonly used drugs in the general practitioner’s office. However, with the increasing popularity of drugs such as semaglutide and liraglutide, questions about the safety of using these medications are also on the rise. It is widely known that drugs such as semaglutide act on receptors GLP-1 and delay gastric emptying, which in the longer time period can lead to gastroparesis. Additionally, patients may experience rapid loss of facial fat due to quick weight loss, leading to a condition known as ‘Ozempic face’. Acute pancreatitis may occur in patients using semaglutide or liraglutide due to the presence of GLP-1 receptors on the pancreatic islets, which can cause hyperplasia and inflammation during the use of these drugs.
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