In contemporary health discourse, individuals are expected to take an active role in maintaining their own health. Health promotion perspectives emphasize well-being and the capacity to cope effectively with stressors. Within this context, sense of coherence and artificial intelligence emerge as concepts of considerable relevance for health. The aim of this study was to examine evidence on the significance of a strong sense of coherence for health and to explore the role of artificial intelligence in health promotion and in supporting processes related to the development of sense of coherence. A narrative review of literature indicates that individuals with a stronger sense of coherence tend to report better physical and mental health outcomes. At the same time, artificial intelligence is increasingly being applied in health care, supporting health, rehabilitation, and digital self-management, offering new opportunities for personalized and accessible health support. The reviewed literature suggests that artificial intelligence may have the potential to contribute to the strengthening of sense of coherence by supporting individuals’ perception of life as more comprehensible, manageable, and meaningful. The findings in this study highlight the importance of integrating salutogenic theory with contemporary digital innovation in order to better understand and support health in modern life.