DISEASES AND PROBLEMS DISTINGUISHED BY WHO AND FAO / RESEARCH PAPER
LIFE EXPECTANCY IN PATIENTS WITH STAGE III A NON-SMALL CELL LUNG CANCER (NSCLC) TREATED WITH NEOADJUVANT CHEMORADIOTHERAPY (NCRT), NEOADJUVANT CHEMOTHERAPY (NCT), NEOADJUVANT CHEMOTHERAPY + ADJUVANT RADIATION THERAPY (NCT + ADJUVANT RT)
1
Department of Oncology, the Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
2
Department of Chest and Mediastinal, National Cancer Institute, Kyiv, Ukraine
3
Department of Statistics, National Cancer Institute, Kyiv, Ukraine
Submission date: 2022-10-14
Final revision date: 2022-11-13
Acceptance date: 2022-11-21
Publication date: 2022-12-30
Corresponding author
Katerina Maliarchuk
Katerina Maliarchuk, Department of Oncology, the Shupyk National Healthcare University of Ukraine, 9 Dorohozhytska St, 04112 Kyiv, Ukraine
Katerina Maliarchuk, Department of Oncology, the Shupyk National Healthcare University of Ukraine, 9 Dorohozhytska St, 04112 Kyiv, Ukraine
Health Prob Civil. 2022;16(4):302-311
KEYWORDS
TOPICS
ABSTRACT
Background:
This work is а comparative study of survival in patients with stage III A non-small cell lung cancer (NSCLC) treated with neoadjuvant chemoradiotherapy (NCRT), neoadjuvant chemotherapy (NCT) and neoadjuvant chemotherapy and adjuvant radiation therapy (NCT + adjuvant RT).
Material and methods:
Three groups of 65 people were selected. The first group received NCT, the second group – NCT, and the third group – NCT + adjuvant radiation therapy. The NCRT group received radiation therapy of 30 Gy. Survival was assessed using the Kaplan and Mayer scale and according to the log rank criteria.
Results:
The statistical criterion for NCRT in relation to NCT was -3.51279, r=0.00044. The statistical criterion for NCRT in relation to NCT + adjuvant RT was -2.88568, r=0.00391. Less reliable dependence was observed between NCT and NCT + adjuvant RT (the statistical criterion =1.809508, p=0.070307).
Conclusions:
Performing NCT, NCRT or NCT + RT and the status of complete morphological response (CMR) during the revision of histological material, it is possible to predict survival for a period of up to 36 months. NCRT is the optimal method of treatment.
This work is а comparative study of survival in patients with stage III A non-small cell lung cancer (NSCLC) treated with neoadjuvant chemoradiotherapy (NCRT), neoadjuvant chemotherapy (NCT) and neoadjuvant chemotherapy and adjuvant radiation therapy (NCT + adjuvant RT).
Material and methods:
Three groups of 65 people were selected. The first group received NCT, the second group – NCT, and the third group – NCT + adjuvant radiation therapy. The NCRT group received radiation therapy of 30 Gy. Survival was assessed using the Kaplan and Mayer scale and according to the log rank criteria.
Results:
The statistical criterion for NCRT in relation to NCT was -3.51279, r=0.00044. The statistical criterion for NCRT in relation to NCT + adjuvant RT was -2.88568, r=0.00391. Less reliable dependence was observed between NCT and NCT + adjuvant RT (the statistical criterion =1.809508, p=0.070307).
Conclusions:
Performing NCT, NCRT or NCT + RT and the status of complete morphological response (CMR) during the revision of histological material, it is possible to predict survival for a period of up to 36 months. NCRT is the optimal method of treatment.
| eISSN: | 2354-0265 |
| ISSN: | 2353-6942 |
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