RESEARCH PAPER
ANALYSIS OF RESISTANCE TO ANTIMYCOBACTERIAL DRUGS AMONG MTBC STRAINS ISOLATED FROM CATTLE IN POLAND AS A THREAT TO HUMAN HEALTH
1
Pope John Paul II State School of Higher Education in Biała Podlaska, Poland
2
National Veterinary Research Institute in Puławy, Poland
3
National Tuberculosis and Lung Diseases Research Institute in Warsaw, Poland
Submission date: 2016-02-23
Acceptance date: 2016-04-06
Publication date: 2020-02-24
Health Prob Civil. 2020;14(1):24-28
KEYWORDS
TOPICS
ABSTRACT
Background:
Tuberculosis is a highly contagious disease affecting humans and animals. It is caused by mycobacteria that are part of the Mycobacterium tuberculosis complex (MTBC). The etiological agent causing bovine tuberculosis is mycobacteria bovis: Mycobacterium bovis and Mycobacterium caprae. According to the World Health Organization bovine tuberculosis is classified as direct zoonosis.
Material and methods:
The study material consisted of 129 MTBC strains isolated from Polish cattle, which were microbiologically analyzed. The resistance phenotype was tested for first-line anti-tuberculosis drugs used in the treatment of tuberculosis in humans. The drugs included streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The MTBC strains tested in this study were isolated from cattle tissue post mortem so that the determination of drug resistance could meet only the epidemiological criterion.
Results:
Polish strains of mycobacteria bovis have not acquired environmental resistance despite the huge dynamics of changes in the phenotype of mycobacterial tuberculosis resistance. Strains classified as M. bovis are characterized by natural resistance to PZA, which is typical of this species.
Conclusions:
Drug resistance imposes the use of additional drugs. Drugs that are less effective than the basic drugs, drugs causing side effects more frequently and drugs that are much more expensive.
Tuberculosis is a highly contagious disease affecting humans and animals. It is caused by mycobacteria that are part of the Mycobacterium tuberculosis complex (MTBC). The etiological agent causing bovine tuberculosis is mycobacteria bovis: Mycobacterium bovis and Mycobacterium caprae. According to the World Health Organization bovine tuberculosis is classified as direct zoonosis.
Material and methods:
The study material consisted of 129 MTBC strains isolated from Polish cattle, which were microbiologically analyzed. The resistance phenotype was tested for first-line anti-tuberculosis drugs used in the treatment of tuberculosis in humans. The drugs included streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The MTBC strains tested in this study were isolated from cattle tissue post mortem so that the determination of drug resistance could meet only the epidemiological criterion.
Results:
Polish strains of mycobacteria bovis have not acquired environmental resistance despite the huge dynamics of changes in the phenotype of mycobacterial tuberculosis resistance. Strains classified as M. bovis are characterized by natural resistance to PZA, which is typical of this species.
Conclusions:
Drug resistance imposes the use of additional drugs. Drugs that are less effective than the basic drugs, drugs causing side effects more frequently and drugs that are much more expensive.
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