REVIEW PAPER
EXTRACELLULAR VESICLES IN THE PATHOGENESIS OF ENDOMETRIOSIS: SCIENTOMETRIC ANALYSIS AND LITERATURE REVIEW
1
Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland
2
Dr Anna Gostynska Wolski Hospital, Independent Public Health Care Institution, Warsaw, Poland
These authors had equal contribution to this work
Submission date: 2025-01-25
Final revision date: 2025-03-03
Acceptance date: 2025-03-06
Publication date: 2025-03-12
KEYWORDS
TOPICS
ABSTRACT
Pain and infertility are the most common symptoms of endometriosis (EMS), a gynecological disorder defined as the development of endometrial cells outside the uterus. Extracellular vesicles (EVs) are physiologically active granules that carry molecular content with both diagnostic and therapeutic implications in intercellular communication. We performed a systematic review based on the 2020 PRISMA guidelines to investigate the role of EVs in EMS. On March 3th, 2024, the keywords “endometriosis”, “extracellular vesicles”, “EV”, or “EVs”, along with the terms “treatment”, “monitoring”, or “diagnosis”, were used to search three databases (Medline, PubMed and Scopus). Articles published in English between 2019 and 2024 were counted. 170 EMS patients from 14 studies were included in the analysis. Samples of EVs of various origins were investigated to find possible relevance in the pathophysiology and their diagnostic and therapeutic implications. The most often analyzed cargo were microRNAs. The possible contribution of EVs to pathophysiology has been examined in a number of studies, with an emphasis on their roles in inflammation, angiogenesis, immunomodulation, cell communication, and proliferation. The reports indicated the involvement of EVs in numerous signaling pathways, including the MAP, WNT, TNF and PI3K-AKT pathways.
REFERENCES (36)
1.
World Health Organization. Endometriosis [Internet]. Geneva: WHO; 2023 March 24 [access December 2024]. Available from: https://www.who.int/news-room/....
2.
Ellis K, Munro D, Clarke J. Endometriosis is undervalued: a call to action. Frontiers in Global Women S Health. 2022; 3. https://doi.org/10.3389/fgwh.2....
3.
Barnard ME, Farland LV, Yan B, Wang J, Trabert B, Doherty JA, et al. Endometriosis typology and ovarian cancer risk. JAMA. 2024; 332(6): 482. https://doi.org/10.1001/jama.2....
4.
Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. The Lancet. 2021; 397(10276): 839-52. https://doi.org/10.1016/s0140-....
5.
Bonavina G, Taylor HS. Endometriosis-associated infertility: from pathophysiology to tailored treatment. Frontiers in Endocrinology. 2022; 13. https://doi.org/10.3389/fendo.....
6.
Bulun SE. Endometriosis caused by retrograde menstruation: now demonstrated by DNA evidence. Fertility and Sterility. 2022; 118(3): 535-6. https://doi.org/10.1016/j.fert....
7.
Lamceva J, Uljanovs R, Strumfa I. The main theories on the pathogenesis of endometriosis. International Journal of Molecular Sciences. 2023; 24(5): 4254. https://doi.org/10.3390/ijms24....
8.
Viganò P, Caprara F, Giola F, Di Stefano G, Somigliana E, Vercellini P. Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates. Human Reproduction Open. 2024; 2024(3). https://doi.org/10.1093/hropen....
9.
McCallion A, Sisnett DJ, Zutautas KB, Hayati D, Spiess KG, Aleksieva S, et al. Endometriosis through an immunological lens: a pathophysiology based in immune dysregulation. Exploration of Immunology. 2022; 454-83. https://doi.org/10.37349/ei.20....
10.
De Carvalho França PR, Lontra ACP, Fernandes PD. Endometriosis: a disease with few direct treatment options. Molecules. 2022; 27(13): 4034. https://doi.org/10.3390/molecu....
11.
Huang Y, Li Q, Hu R, Li R, Yang Y. Five immune-related genes as diagnostic markers for endometriosis and their correlation with immune infiltration. Frontiers in Endocrinology. 2022; 13. https://doi.org/10.3389/fendo.....
12.
Wang Y, Dragovic RA, Greaves E, Becker CM, Southcombe JH. Macrophages and small extracellular vesicle mediated-intracellular communication in the peritoneal microenvironment: Impact on endometriosis development. Frontiers in Reproductive Health. 2023; 5. Available from: https://doi.org/10.3389/frph.2....
13.
Di Bella MA. Overview and update on extracellular vesicles: considerations on exosomes and their application in modern medicine. Biology. 2022; 11(6): 804. https://doi.org/10.3390/biolog....
14.
Uddin MJ, Mohite P, Munde S, Ade N, Oladosu TA, Chidrawar VR, et al. Extracellular vesicles: the future of therapeutics and drug delivery systems. Intelligent Pharmacy. 2024; 2(3): 312-28. https://doi.org/10.1016/j.ipha....
15.
Wang M, Zheng L, Lin R, Ma S, Li J, Yang S. A comprehensive overview of exosome lncRNAs: emerging biomarkers and potential therapeutics in endometriosis. Frontiers in Endocrinology. 2023; 14. https://doi.org/10.3389/fendo.....
16.
Devi TR, Kadalmani B, Devi CA. Novel methods in diagnosis of endometriosis in future. International Journal of Reproduction Contraception Obstetrics and Gynecology. 2022; 11(6): 1824. https://doi.org/10.18203/2320-....
17.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372: n71. https://doi.org/10.1136/bmj.n7....
18.
Asl FD, Sahraei SS, Kalhor N, Fazaeli H, Sheykhhasan M, Moud SS, et al. Promising effects of exosomes from menstrual blood-derived mesenchymal stem cells on endometriosis. Reproductive Biology. 2023; 23(3): 100788. https://doi.org/10.1016/j.repb....
19.
Hsu CY, Hsieh TH, Lin HY, Lu CY, Lo HW, Tsai CC, et al. Characterization and proteomic analysis of endometrial stromal Cell–Derived small extracellular vesicles. The Journal of Clinical Endocrinology & Metabolism. 2021; 106(5): 1516-29. https://doi.org/10.1210/clinem....
20.
Wang X, Wu P, Li X, Zeng C, Zhu J, Zhou Y, et al. Extracellular vesicles inhibit proliferation and invasion of ovarian endometrial stromal cells and their expression of SF-1, ERΒ, and aromatase. Frontiers in Endocrinology. 2021; 12. https://doi.org/10.3389/fendo.....
21.
Zhou W, Lian Y, Jiang J, Wang L, Ren L, Li Y, et al. Differential expression of microRNA in exosomes derived from endometrial stromal cells of women with endometriosis-associated infertility. Reproductive BioMedicine Online. 2020; 41(2): 170-81. https://doi.org/10.1016/j.rbmo....
22.
Qiu JJ, Lin XJ, Zheng TT, Tang XY, Zhang Y, Hua KQ. The exosomal long noncoding RNA aHIF is upregulated in serum from patients with endometriosis and promotes angiogenesis in endometriosis. Reproductive Sciences. 2019; 26(12): 1590-602. https://doi.org/10.1177/193371....
23.
Huang Y, Zhu L, Li H, Ye J, Lin N, Chen M, et al. Endometriosis derived exosomal miR-301a-3p mediates macrophage polarization via regulating PTEN-PI3K axis. Biomedicine & Pharmacotherapy. 2022; 147: 112680. https://doi.org/10.1016/j.biop....
24.
Khalaj K, Miller JE, Lingegowda H, Fazleabas AT, Young SL, Lessey BA, et al. Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. JCI Insight. 2019; 4(18). https://doi.org/10.1172/jci.in....
25.
Wu J, Fang X, Huang H, Huang W, Wang L, Xia X. Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network. Aging. 2021; 13(9): 12607-30. https://doi.org/10.18632/aging....
26.
Feng Y, Zhan F, Zhong Y, Tan B. Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells. Molecular Medicine Reports. 2020; 22(2): 715-22. https://doi.org/10.3892/mmr.20....
27.
Wu J, Huang H, Huang W, Wang L, Xia X, Fang X. Analysis of exosomal lNCRNA, MIRNA and mRNA expression profiles and CERNA network construction in endometriosis. Epigenomics. 2020; 12(14): 1193-213. https://doi.org/10.2217/epi-20....
28.
Li Y, Cui S, Xu Z, Zhang Y, Wu T, Zhang J, et al. Exosomal tRF-Leu-AAG-001 derived from mast cell as a potential non-invasive diagnostic biomarker for endometriosis. BMC Women S Health. 2022; 22(1). https://doi.org/10.1186/s12905....
29.
Wu Y, Yuan W, Ding H, Wu X. Serum exosomal miRNA from endometriosis patients correlates with disease severity. Archives of Gynecology and Obstetrics. 2021; 305(1): 117-27. https://doi.org/10.1007/s00404....
30.
Huang Y, Zhang D, Zhou Y, Peng C. Identification of a serum exosome-derived lncRNA‒miRNA‒mRNA ceRNA network in patients with endometriosis. Clinical and Experimental Obstetrics & Gynecology. 2024; 51(2). https://doi.org/10.31083/j.ceo....
31.
Zhang Y, Zhang H, Yan L, Liang G, Zhu C, Wang Y, et al. Exosomal microRNAs in tubal fluid may be involved in damage to tubal reproductive function associated with tubal endometriosis. Reproductive BioMedicine Online. 2023; 47(4): 103249. https://doi.org/10.1016/j.rbmo....
32.
Horne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022; e070750. https://doi.org/10.1136/bmj-20....
33.
Signorile PG, Viceconte R, Baldi A. New insights in pathogenesis of endometriosis. Frontiers in Medicine. 2022; 9. https://doi.org/10.3389/fmed.2....
34.
Giudice LC, Kao LC. Endometriosis. The Lancet. 2004; 364(9447): 1789-99. https://doi.org/10.1016/s0140-....
35.
Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertility and Sterility. 2012; 98(3): 511-9. https://doi.org/10.1016/j.fert....
36.
Laganà AS, Garzon S, Götte M, Viganò P, Franchi M, Ghezzi F, et al. The pathogenesis of endometriosis: molecular and cell biology insights. International Journal of Molecular Sciences. 2019; 20(22): 5615. https://doi.org/10.3390/ijms20....
Share
RELATED ARTICLE
| eISSN: | 2354-0265 |
| ISSN: | 2353-6942 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
