The article focuses on the identification of the main preventive strategies employed in countering respiratory diseases with the risk of pandemic transmission (influenza and COVID-19). The research aimed to create a literature review focusing on preventive measures and strategies to minimize the occurrence and spread of respiratory diseases among employees in private businesses. These findings are intended to be employed to develop a preventive economic model for organizations in the Czech Republic against the spread of respiratory diseases. Data were obtained by systematically selecting studies from scientific databases (EBSCO host, Ovid, Scopus, Web of Science) and studying the hygienic recommendations of regional and government experts relevant to the objectives of this study. Based on a set of PICO questions and using a three-stage search, the authors analyzed a total of 1102 relevant scientific articles, and, subsequently, 15 relevant recommendations issued by the main experts of the Ministry of Health and other bodies of the Czech Republic between March 2020 and February 2022. The published studies point to a wide range of recommended preventive strategies against the occurrence and spread of respiratory diseases. The authors have proposed an organizational model that may strengthen preventive care in selected fields.