DISEASES AND PROBLEMS DISTINGUISHED BY WHO AND FAO / RESEARCH PAPER
THE ROLE OF COMPONENT-BASED DIAGNOSTICS IN HAZELNUT ALLERGY TESTING
1
Faculty of Health Sciences, University of Miskolc, Hungary
2
Borsod-Abaúj-Zemplén County Central Hospital and University Teaching Hospital, Miskolc, Hungary
Submission date: 2023-08-04
Final revision date: 2023-09-06
Acceptance date: 2023-09-07
Publication date: 2023-09-20
Health Prob Civil. 2023;17(4):299-305
KEYWORDS
TOPICS
ABSTRACT
Background:
Allergies have become a widespread disease in all parts of the world. Allergic diseases affect nearly 30% of the population in Hungary, of which food allergies account for a significant proportion. In this paper we analyzed the prevalence of hazelnut allergy.
Material and methods:
In the present study, the sensitivity to hazelnut, a specific and otherwise heathy food component, was investigated comparing it with the self-reported symptoms of the participants, and Component-Resolved Diagnostic (CRD) method. In the study a total of 229 persons were included, 87 men and 142 women.
Results:
Molecular allergy testing showed some serum immunoglobulin E level elevation related to hazelnut in 20 participants of which 1 individual was asymptomatic but CRD positive for hazelnut. There was positivity in 90% of the cases for the component Cor a 1, which is perhaps a consequence of a cross-reaction to the homologous component Bet v 1 of birch pollen. In 10% of cases, sensitization to components of Cor a 8 was found, which may be a consequence of cross-reactivity to the lipid transfer protein (LTP) component of other foods.
Conclusions:
Knowledge of hazelnut sensitization may be important for people affected, as avoiding consumption of raw hazelnut may theoretically prevent the development of hazelnut allergy.
Allergies have become a widespread disease in all parts of the world. Allergic diseases affect nearly 30% of the population in Hungary, of which food allergies account for a significant proportion. In this paper we analyzed the prevalence of hazelnut allergy.
Material and methods:
In the present study, the sensitivity to hazelnut, a specific and otherwise heathy food component, was investigated comparing it with the self-reported symptoms of the participants, and Component-Resolved Diagnostic (CRD) method. In the study a total of 229 persons were included, 87 men and 142 women.
Results:
Molecular allergy testing showed some serum immunoglobulin E level elevation related to hazelnut in 20 participants of which 1 individual was asymptomatic but CRD positive for hazelnut. There was positivity in 90% of the cases for the component Cor a 1, which is perhaps a consequence of a cross-reaction to the homologous component Bet v 1 of birch pollen. In 10% of cases, sensitization to components of Cor a 8 was found, which may be a consequence of cross-reactivity to the lipid transfer protein (LTP) component of other foods.
Conclusions:
Knowledge of hazelnut sensitization may be important for people affected, as avoiding consumption of raw hazelnut may theoretically prevent the development of hazelnut allergy.
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| eISSN: | 2354-0265 |
| ISSN: | 2353-6942 |
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